130 articles - From Friday Apr 11 2025 to Friday Apr 18 2025
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
| Clin Gastroenterol Hepatol |
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Defining radiological healing in perianal fistulising Crohn's Disease: a TOpClass global expert Delphi consensus. This international Delphi consensus standardizes radiological endpoints in pfCD, improving consistency in clinical and research settings. Future studies will validate this definition and assess how radiological changes predict long-term clinical outcomes and quality of life improvements. |
| Gastroenterology |
Global Consensus Recommendations for Metabolic Dysfunction-Associated Steatotic Liver Disease and Steatohepatitis. Our study provides an extensive set of recommendations generated based on a comprehensive review of the most recent MASLD/MASH guidelines and a consensus-building process. |
meta-analyses and systematic reviews
| Clin Gastroenterol Hepatol |
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Change in cT1 following interventions in MASLD: A systematic review and meta-analysis. Evidence to-date supports a significant treatment-induced reduction in cT1 as compared to minimal changes in the placebo group. Our findings could inform study designs for investigational therapies and support monitoring of treatment response in individuals with MASLD in clinical trials and clinical practice. |
| Gastrointest Endosc |
A systematic review of technical factors associated with persistent fistula after endoscopic ultrasound-directed transgastric endoscopic retrograde cholangiopancreatography in patients with Roux-en-Y gastric bypass. In this systematic review, larger stent size, passive (spontaneous) closure after stent removal, and longer stent dwell time appeared associated with an increased risk of PF formation after EDGE. |
Outcomes and Safety of Duodenal Endoscopic Submucosal Dissection for non-ampullary lesion: a systematic review and meta-analysis. ESD for NADL can be considered an alternative to standard techniques or surgery when en-bloc and R0 resection is requested. High experience and proficiency are required to replicate the outcomes found by this meta-analysis. |
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
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Clinical Trial: A Multicentre Randomised Controlled Trial of Carvedilol Versus Variceal Band Ligation in Primary Prevention of Variceal Bleeding in Liver Cirrhosis (CALIBRE Trial). The early terminated and, thus, underpowered CALIBRE trial showed no difference between carvedilol and VBL in the primary prevention of variceal bleeding in patients with cirrhosis and medium-to large-sized oesophageal varices. No untoward safety concerns were noted. |
The Impact of Antispasmodic Use on Abdominal Pain and Opioid Use in Inflammatory Bowel Disease: A Population-Based Study. Antispasmodic use in patients with IBD was associated with increased abdominal pain and opioid use in opioid-naïve patients. Antispasmodic use was associated with increased likelihood of corticosteroid use, clinic and ER visits and hospitalisation. |
| Am J Gastroenterol |
Adenoma Detection Rates Calculated Using All Exams Are Associated with Lower Risk for Post Colonoscopy Colorectal Cancer: Data From the New Hampshire Colonoscopy Registry. Our data demonstrating lower PCCRC risk in exams performed by endoscopists with higher ADR's calculated with al exams helps to validate ADR-A as a quality measure. ADR-A may also increase precision of the calculated ADR. Endoscopists should strive for a higher ADR-A with 44% as an aspirational target. |
Effectiveness of a model of care based on Fibrosis-4 and liver stiffness measurement for the screening of patients with type 2 diabetes mellitus at risk of advanced liver disease: results from an Italian prospective multicentre study. In diabetes clinics, the 2-tier screening using FIB-4 and VCTE is effective for the identification of T2DM patients to be referred to hepatologists. VCTE referral may be considered for patients with overweight/obesity and elevated ALT classified as at low risk of advanced liver fibrosis by FIB-4. |
Quantifying Patient Preferences for Risk Tolerance With Novel Dual Biologic Therapies for Inflammatory Bowel Disease. The findings suggest that patients prefer safe and efficacious treatments and DBT may be an acceptable option for those who have failed an advanced therapy for IBD. We demonstrate the value of building on existing evidence and designing efficient DCE studies to address knowledge gaps to improve IBD care. |
Rural-urban disparities in hepatocellular carcinoma deaths are driven by hepatitis C-related HCC. Annual increases in HCC deaths have been more pronounced in rural compared to urban populations. Deaths from HCV-related HCC have declined with a geographical disparity that favors urban populations, possibly driven by decreased access to HCV screening or availability of highly effective direct-acting antiviral therapies for rural residents. These findings underscore the need for targeted HCV screening and treatment strategies in rural populations in addition to ongoing strategies to combat alcohol use and metabolic diseases. |
| Clin Gastroenterol Hepatol |
Comparative Effectiveness of Infliximab vs Ustekinumab for Endoscopic and Transmural Remission in Biologic Naïve Crohn's Disease. Infliximab and ustekinumab demonstrated similar effectiveness in achieving clinical, endoscopic, and transmural remission in biologic-naïve patients with CD. |
Development of a question prompt list for people living with primary biliary cholangitis - A Delphi Study. In addition, one question regarding first-line therapy was included despite being rated as moderately/very important by 68.5%. The PBC patient question prompt list serves as a user-facing document, to enhance the patient experience, and drive value-based healthcare in routine clinical practice. |
Hepatic encephalopathy and MELD-Na predict treatment benefit in autoimmune hepatitis-related decompensated cirrhosis. Immunosuppression is beneficial in patients with AIH-related decompensated cirrhosis and active disease. OHE and MELD-Na at diagnosis, along with a decline in MELD-Na at 4 weeks of treatment, are the most important determinants of outcome and can guide treatment decisions. |
Postoperative Outcomes in Tofacitinib-treated Patients with Acute Severe Ulcerative Colitis Undergoing Colectomy. We observed a significantly lower rate of overall postoperative complications in ASUC patients treated with tofacitinib compared to infliximab; however, no difference was observed in the risk for serious postoperative complications. Larger prospective trials are needed to confirm these findings. |
Spleen stiffness predicts the risk of liver-related complications in patients with compensated advanced chronic liver disease. Non-invasive assessment using SSM may serve as an excellent tool for predicting the risk of liver-related complications and risk-stratifying patients with cACLD, thereby improving their management. |
| Endosc Int Open |
Association of semaglutide with retained gastric contents on endoscopy: Retrospective analysis. Semaglutide use appears to increase risk of having retained gastric contents visualized during endoscopy. Patients on semaglutide for weight loss appear to have a greater risk of RGC compared with patients on semaglutide for glycemic control. This observation may have clinical implications for management of GLP-1 agonist use prior to endoscopy. |
Diagnosis of small bowel inflammation using small bowel capsule endoscopy combined with abdominal CT scan. We evaluated presence or absence of mucosal inflammation by SBCE in patients with CT findings of suspected small bowel inflammation and analyzed their backgrounds. Patients and methods The Lewis score was determined by SBCE, and scores ≥ 135 placed 65 patients in the enteritis group and scores of 4.15 mm) on CT has these characteristics, it may be worth considering performing SBCE. |
Differences in colonoscopy performance among four endoscopy centers in Western Norway: Influence of case-mix. Case-mix influenced performance measures. Although we showed center differences in performance, other factors, such as individual endoscopist skills, probably influence performance measures. Our study demonstrates the importance of considering case-mix when assessing colonoscopy performance. |
Efficacy and safety of multi-loop traction device-assisted colorectal endoscopic submucosal dissection: Multicenter randomized clinical trial. This multicenter randomized trial demonstrated that use of MLTD did not significantly increase dissection speed for colorectal ESD. Treatment conversions may have influenced the primary endpoint, and further investigation is warranted. |
Endoscopic intermuscular dissection for management of 10- to 20-mm rectal neuroendocrine tumors: Pilot study (with video). EID is a promising treatment for 10- to 20-mm R-NETs, with high initial cure rates, and a new option for endoscopic resection. More studies of the procedure are needed. |
Endoscopic ultrasound-guided therapies versus retrograde transvenous obliteration for gastric varices: Multicenter propensity matched analysis. EUS-guided therapy offers a safe and effective alternative to RTO for managing fundal varices. Although reintervention rate for GVs were higher than for EUS, incidence of AEs and reintervention for EVs was higher with RTO. |
Optimal timing for discontinuation of ERCP in cases of difficult selective biliary cannulation. In cases of difficult SBC, discontinuing attempts at around 8 minutes may minimize risk of PEP. However, extending attempts up to 12 minutes can be justified to achieve higher success rates. Beyond 12 minutes, likelihood of successful SBC diminishes significantly. |
Optimizing endoscopic detection of precancerous gastric conditions: Single-center prospective study. Despite the diverse hospital population, ASAG prevalence remained low. A numerical increase in ASAG detection rate was observed with systematic NBI use compared with optional NBI use. Overall, systematic NBI-guided biopsies appear to be associated with increased rates of detection of ASAG, atrophy, and IM. |
Outcomes of retained gastrointestinal debris during upper endoscopy. Our study did not demonstrate a significant increase in post-procedure complications in patients with GIDR. Further, the GIDR group had higher rates of opiate use, which can guide stratification of retention risk. |
Transpapillary biliary drainage using a forward-viewing endoscope for patients with distal malignant biliary obstruction and type I duodenal stenosis. Transpapillary biliary drainage using a forward-viewing endoscope is a useful option for patients with type I duodenal stenosis. |
| Endoscopy |
Endoscopic direct diverticulitis therapy for acute uncomplicated diverticulitis. EDDT utilizing cholangioscope-assisted colonoscopy is a feasible alternative treatment for acute uncomplicated diverticulitis, offering diagnostic and therapeutic advantages through direct visualization. With promising preliminary results, further studies with larger cohorts are warranted to confirm its efficacy and long-term outcomes. |
Endoscopic ultrasound-guided choledochoduodenostomy results in fewer complications than percutaneous drainage following failed ERCP in malignant distal biliary obstruction. When both modalities were available and technically feasible, gastroenterologists preferred EUS-CDS over PTBD. EUS-CDS seems to be associated with a lower mortality and AE rate, shorter hospital admission and fewer reinterventions, but a randomized controlled trial should confirm these observations. |
| Gastroenterology |
Generative Artificial Intelligence in Clinical Medicine and Impact on Gastroenterology. We remain optimistic in the potential of GenAI to augment clinical expertise due to the adaptability of GenAI to handle multiple data modalities to obtain and focus relevant information flows and the human-friendly interfaces that facilitate ease of use. We believe that the potential of GenAI for dynamic human-algorithmic interactions may allow for a degree of clinician-directed customization to enhance human presence. |
Preventive effect of Helicobacter pylori treatment on gastric cancer incidence and mortality: A Korean population study. HPE may help prevent GC and improve survival in adults of al ages, including those aged ≥70 years. These findings suggest that HPE benefits not only younger adults but also older adults. HPE treatment is preferable at a younger age, but older age may not be a limiting factor for the treatment. |
Therapeutic Targeting of Oncogene-induced Transcription-Replication Conflicts in Pancreatic Ductal Adenocarcinoma. AOH1996 safely and effectively targets TRCs in preclinical PDAC models, with initial clinical evidence supporting its potential for treating chemotherapy-refractory PDAC. Further clinical development is warranted. |
| Gastrointest Endosc |
A Combined Endoscopy and Functional Lumen Imaging Probe Panometry Approach Can Expedite Diagnosis of Esophageal Motility Disorders. An approach utilizing endoscopy (CARS score) and FLIP Panometry (EndoMAP) identified actionable esophageal motility disorders at the point-of-care endoscopy encounter. While additional validation is planned, this approach offers a well-tolerated method that addresses limitations of HRM. Applied to the index endoscopic encounter, this approach could expedite management, reducing need for HRM in some patients versus triaging toward additional testing in others. |
Short- and long-term outcomes of endoscopic resection for gastric tube cancer: A Japanese multicenter prospective cohort study. ER could be safely performed for gastric tube cancer; however, its long-term prognosis is worse than that of naïve stomach cancer. Assessing various systemic conditions when deciding on a treatment strategy for gastric tube cancer is important. |
Short-term outcomes of ESD for suspected T1 colorectal cancers: A European experience. ESD performed on polyps with suspected d-SMIC showed lower VM-R0 rates for pT1Sm2-3 cases compared to suspected s-SMIC cases. This should be taken into account when selecting the optimal resection technique for suspected d-SMIC cases. |
Success and Safety of Conventional Endoscopic Resection Techniques for Previously Partially Resected Colorectal Polyps at a Tertiary Referral Center. While specialized resection techniques are increasingly advocated to manage fibrotic colorectal lesions, we demonstrate conclusively that experts can successfully and safely manage previously partially resected colorectal lesions using conventional techniques. |
| Gut |
Choice of colon capsule or colonoscopy versus default colonoscopy in FIT positive patients in the Danish screening programme: a parallel group randomised controlled trial. Offering CCE as an alternative to colonoscopy did not significantly alter the detection rate of advanced neoplasia, nor did it increase uptake in a screening programme with high adherence to colonoscopy following a positive FIT test. Instead, it led to a very high rate of secondary colonoscopies. Therefore, CCE cannot be recommended in this setting. |
Precision risk stratification of primary gastric cancer after eradication of <i>H. pylori</i> by a DNA methylation marker: a multicentre prospective study. Background Precision cancer risk stratification for gastric cancer is urgently needed for the growing number of healthy people after eradication even though al of them have clinically high risk. Individuals with super-high risk will need more frequent gastric cancer screening than currently recommended. |
| Hepatology |
Cirrhosis and age are key determinants of HCC risk in individuals with primary sclerosing cholangitis: A multicenter longitudinal cohort study. Hepatocellular carcinoma is relatively rare in patients with primary sclerosing cholangitis who do not have cirrhosis, especially in those under the age of 50. Our findings indicate that HCC monitoring for patients with PSC can be tailored, based on their age and cirrhosis status. |
Developing palliative care interventions in liver disease using formative and summative qualitative evaluation. Specifically, we sought to understand how the intervention was enacted (fidelity) and to provide a roadmap for future palliative care practice integration in ESLD. In conclusion, formative and summative evaluations play a vital role in improving interventions so that valuable and scarce palliative care resources are applied equitably and effectively and so that patients and their caregivers experience the best possible care and quality of life as they live with ESLD. |
Multiomics approaches for identifying the PANoptosis signature and prognostic model via a multimachine-learning computational framework for intrahepatic cholangiocarcinoma. The present study identified a precise prognostic and treatment strategy for ICC patients prone to PANoptosis, investigated the molecular mechanisms of PANoptosis in ICC cells, and highlighted the potential clinical relevance of the PANRS in predicting prognosis and therapy response. These findings will help guide clinical treatment strategies for ICC. |
| J Hepatol |
Five-year overall survival update from the HIMALAYA study of tremelimumab plus durvalumab in unresectable HCC. At 5 years, STRIDE sustained an OS benefit versus sorafenib and maintained a manageable safety profile. OS benefit with STRIDE was improved in participants with disease control. Data suggest that any degree of tumour shrinkage with STRIDE can be associated with improved OS, indicating that conventional response measures may not fully capture STRIDE benefits. Nevertheless, participants experiencing deep responses appear to have the greatest benefit. STRIDE continues to set new benchmarks in uHCC with 1 in 5 patients alive at 5 years. Impact and implications The phase III HIMALAYA study showed that STRIDE (Single Tremelimumab Regular Interval Durvalumab) improved overall survival (OS) versus sorafenib in participants with unresectable HCC (uHCC), including after 4 years of follow-up. Understanding the efficacy and safety of STRIDE over the longer term is important for healthcare providers; here, we demonstrate that STRIDE sustained an OS benefit versus sorafenib and maintained a manageable safety profile after 5 years of follow-up. OS benefit with STRIDE was improved in participants with disease control and any degree of tumour shrinkage, indicating that conventional response measures may not fully capture the benefits of STRIDE. These findings are important as they set new benchmarks in uHCC and may help guide clinical decisions in the future. |
Machine learning based radiomic models outperform clinical biomarkers in predicting outcomes after immunotherapy for hepatocellular carcinoma. This study used deep learning and machine learning to develop and validate an integrated radiomic-clinical model which can predict survival and response to atezolizumab plus bevacizumab from pre-treatment imaging. Radiomic-based machine learning models can risk-stratify advanced HCC patients receiving atezolizumab plus bevacizumab. |
Phosphatidylethanol levels distinguish steatotic liver disease subgroups and are associated with risk of major liver outcomes. PEth is a valuable alcohol biomarker for distinguishing between SLD subtypes, especially ALD, and predicts adverse outcomes in people with and without SLD. Impact and implications There is controversy regarding the various proposed steatotic liver disease (SLD) subtypes, the most recent definition suggesting that patients with an elevated alcohol consumption and MASLD should be classified as having MetALD. Here, we address this challenge by classifying patients with SLD by utilizing the biomarker phosphatidylethanol (PEth), a direct and reliable biomarker for recent alcohol consumption. Our analysis of this large cohort-comprising 46,406 patients-revealed that using the objective PEth biomarker may be a valuable tool for distinguishing between MASLD and MetALD, and that PEth is strongly associated with the risk of liver outcomes in individuals with and without known SLD. Integrating PEth testing into routine diagnostic evaluations could enhance knowledge on the underlying pathophysiology in SLD, reduce the potential for misclassification, and ultimately improve patient outcomes by enabling clinicians to offer appropriate therapies. Further research is needed to validate these findings in other populations and to explore the potential integration of PEth into broader clinical guidelines for managing SLD. |
Regulation of KIF23 by miR-107 controls replicative tumor cell fitness in mouse and human hepatocellular carcinoma. Disruption of the miR-107/Kif23 axis inhibited hepatoma cell proliferation in vitro and prevented oncogene-induced liver cancer development in vivo, offering a novel potential avenue for the treatment of HCC in humans. Impact and implications Our study revealed the central role of the miR-107/KIF23 axis in controlling tumor cell fitness and hepatocellular carcinoma progression. The results demonstrate that the overexpression of miR-107 or silencing of its target, KIF23, markedly suppresses the proliferation, survival, and motility of human and mouse hepatoma cells. In this work, we demonstrate that the disruption of miR-107/Kif23 signaling effectively protects mice from an aggressive form of oncogene-induced liver cancer in vivo, implying that targeting miR-107/KIF23 might be a novel therapeutic approach for hepatocellular carcinoma in humans. |
Tumor-Derived CD109 Orchestrates Reprogramming of Tumor-Associated Macrophages to Dampen Immune Response. Our findings reveal sCD109 as a 'secreted immune checkpoint' that reprograms the TIME and suggest that CD109 inhibition is a valuable strategy to sensitize the effectiveness of iCCA immunotherapy. Impact and implications Poor response to tumor immunotherapy in patients with intrahepatic cholangiocarcinoma (iCCA) has long been a challenge for clinicians. In this study, we used multiomics approaches to elucidate that tumor cells secrete soluble CD109, which reprograms macrophages, leading to the accumulation of CD73 + macrophages in the tumor immune microenvironment (TIME). This effect significantly inhibits T cell proliferation and the immune response of CD8 + T cells, thereby impairing the efficacy of immunotherapy. In preclinical studies, we demonstrated that targeting CD109 in mice can markedly improve the immunosuppressive TIME, sensitizing iCCA cells to anti-PD-L1 immunotherapy. These findings represent a crucial step toward developing more effective therapies for iCCA and have significant implications for clinicians, scientists, and drug developers in the field. |
Validation and expansion of Baveno VII recompensation criteria in patients with cirrhosis and curable liver disease. Baveno-VII criteria identify cirrhotic patients with a good prognosis, but fewer than 10% of decompensated patients achieve recompensation. Expanding these criteria to include patients receiving minimal decompensation treatment identifies those with similarly low mortality risk. Impact and implications In recent years, growing evidence has shown that achieving an etiological cure can significantly improve the prognosis of decompensated patients, leading to the development of the concept of recompensation. Baveno VII recently proposed a definition for recompensation; however, data on the clinical impact of this condition remain limited. In this study we evaluated Baveno VII criteria and developed and validated expanded Baveno VII criteria for recompensation. Our findings demonstrates that recompensation is associated with improved survival, reduced hyperdynamic circulation and decreased systemic inflammation in outpatients with decompensated cirrhosis. These results are valuable for hepatologists and researchers aiming to refine patient management strategies and risk stratification in cirrhosis care. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Aliment Pharmacol Ther |
|---|
| Clin Gastroenterol Hepatol |
Artificial Intelligence for Clinical Trial Facilitation, Lessons for Inflammatory Bowel Disease: A Scoping Review. Notwithstanding the ethical, regulatory, and practical limitations, incorporation of AI into clinical trials may accelerate and improve quality of drug development in IBD. |
| Gastroenterology |
Acute Pancreatitis in Children: It's Not Just a Simple Attack. Our review highlights for the first time how AP can lead to significant long-term sequelae, including exocrine/nutritional deficiencies, endocrine pancreatic dysfunction, diabetes, recurrent pain, and decreased quality of life compared to healthy population controls. The goal of this review is to summarize advances in understanding of pediatric AP and to emphasize the importance of early recognition, appropriate risk stratification, and comprehensive follow-up after the first pediatric AP episode, while highlighting areas requiring future research to optimize patient outcomes. |
| Gut |
Cellular and molecular mechanisms in the pathogenesis of pouchitis: more than just the microbiota. In addition, we introduce the concept of pouchitis as a possible transmural disease and discuss the potential role of non-immune cells, including stromal cells, in perpetuating inflammation and intestinal barrier dysfunction. We discuss future directions, implications for novel therapies and propose novel multicellular disease models that can better capture the complexity of pouchitis pathogenesis. |
| J Hepatol |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Am J Gastroenterol |
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| Clin Gastroenterol Hepatol |
| Endosc Int Open |
| Endoscopy |
| Gastrointest Endosc |
| Hepatology |
| J Hepatol |
Letters to the editors and authors’ replies
| Aliment Pharmacol Ther |
|---|
| Clin Gastroenterol Hepatol |
| Gastroenterology |
| Gut |
| J Hepatol |